Table 1.
Sequence differences between LEW and SHR mitochondrial DNA
| AA Character Hydrophobic/-philic R-chain | ||||||||
|---|---|---|---|---|---|---|---|---|
| Gene | AA No. | Rat LEW | Rat SHR | Human | Relevant Human mtDNA Site | Nearby Human Pathology Mutation, AA No. | LEW | SHR |
| mt-Nd2 | 18 | Val | Ala | Leu | hu 4522 | LHON | hydrophobic | tiny |
| 4640C>A, Ile57Met | nonpolar, aliphatic | nonpolar | ||||||
| 356 | Ala | Thr | Ala | hu 11825 | exercise intolerance/oncocytoma | tiny | hydrophilic | |
| 11832G>A, Trp358Ter | nonpolar | polar, OH | ||||||
| 401 | Val | Ile | Leu | hu 11960 | OAT | hydrophobic | hydrophobic | |
| 11994C>T, Thr412Ile | nonpolar, aliphatic | nonpolar, aliphatic | ||||||
| diabetes mellitus | hydrophobic | hydrophobic | ||||||
| mt-Nd4 | 419 | Pro | Leu | Leu | hu 12014 | 12026A>G, Ile423Val | nonpolar, cyclic | nonpolar, aliphatic |
| mitochondrial myopathy and renal failure | tiny | hydrophilic | ||||||
| mt-Nd5 | 37 | Ala | Thr | Lys | hu 12445 | 12425A-del, N30-frameshift | nonpolar | polar, OH |
AA, amino acid; LHON, Leber hereditary optic neuropathy; OAT, oligoasthenoteratozoospermia.