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p53 expression in K562 cells suppresses polyploidization upon PMA-induced terminal megakaryocytic (Mk) differentiation. A: % polyploidy (≥8N ploidy) among p53-expressing (p53-1 and p53-2) and control (MT) K562 cells undergoing Mk differentiation. Error bars: SE, n = 4. *P ≤ 0.02 (2-tailed paired t-test). B: representative Mk ploidy histograms of MT, p53-1, and p53-2 K562 cells undergoing Mk differentiation on days 1, 5, and 10 after PMA treatment.
