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Expression of p53 in K562 cells promotes apoptosis and cell death upon PMA-induced Mk differentiation. A: binding of annexin V was measured in cultures of p53-expressing (p53-1 and p53-2) and control (MT) K562 cells on days 1, 3, 5, 7, 10, and 12 after PMA treatment. Error bars: SE, n = 4. B: viability assessed by exclusion of TOPRO3 was measured at the same time points. Error bars: SE, n = 4. *P < 0.04 (2-tailed paired t-test).
