Fig. 4.

Histological evaluation of glomerular injury in S and S.SHR(11) rats at week 12. Individual glomeruli were scored on a scale from 0 (normal) to 4 (global sclerosis). Glomerular scores are denoted by individual tick marks. Representative images [×40 hematoxylin and eosin (H&E)] of individual glomeruli demonstrating normal to significant abnormalities including mesangial expansion, glomerulosclerosis, etc. are shown in the right panel. A minimum of 20 randomly selected glomeruli (H&E at ×40) were assessed for degree of glomerulosclerosis and mesangial expansion for each animal (n = 8, per group). *Significantly different between S and S.SHR(11) at P < 0.05.