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Renal ischemia-reperfusion (IR) injury in S, S.SHR(11), and SHR rats at week 8. A: measurement of serum creatinine. B: representative light microscopy images (×40 H&E) of tubule-interstitial region. Necrotic tubules are denoted by an arrow. The S.SHR(11) animals exhibit significantly greater renal injury. Numbers in parenthesis indicate number of rats studied in each group. *P < 0.05 between IR and Sham for each group. †P < 0.05 between S.SHR(11) and either S or SHR.
