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. Author manuscript; available in PMC: 2013 Aug 15.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 3;22(16):5190–5194. doi: 10.1016/j.bmcl.2012.06.080

Table 2.

Effect of BA derivatives on HIV BVM-resistant viruses.

Compound	EC₅₀ (μM)				Toxicity^b TD₅₀ (μM)
Compound	NL4-3^a	V370A^a	ΔT371^b,^c	ΔV370^b,^c	Toxicity^b TD₅₀ (μM)
BVM	0.076	>4	>4	>4	>10, <20
1 (A43D)	0.12±0.08	0.19±0.35	0.027	0.006	12.6
2	0.36±0.09	0.09±0.11	ND^c	ND	7.4
13	1.72±0.83	0.02±0.02	ND	ND	4.8
15	0.19±0.14	0.05±0.03	0.026	0.023	15.0
38	0.58±0.74	0.02±0.01	ND	ND	4.6
39	0.83±0.37	0.24±0.28	ND	ND	18.6
TMC-278	0.00055 ±0.00014	0.00052 ±0.00011	ND	ND	>0.1

^a

Data is the mean of two or more independent experiments and standard deviation.

^b

Data is the average of two independent experiments.

^c

ND = not determined.