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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jul 3;22(16):5190–5194. doi: 10.1016/j.bmcl.2012.06.080

Table 3.

Microsomal stability of BA derivatives.

Compound Terfenadine A43D 2 13 15 38 39
in vitro t1/2 (min)a 29.87 25.48 18.93 30.13 41.01 31.64 24.75
CLint (ml/min/mg)a 0.232 0.272 0.366 0.230 0.169 0.219 0.280
a

Average of two separated experiments with linear regression R2 > 0.95.