Table 7.

O-linked glycans released from total plasma glycoprotein from girls with well-managed galactosemia who do and do not demonstrate ovarian dysfunction as evidenced by AMH value. Patient number, gender, age at blood draw, AMH at blood draw, and GALT genotype are listed.

Glycan structure	Reference range from 40 controls	P8 ♀	P9 ♀	P12 ♀	P10 ♀	P11 ♀	P13 ♀	P14 ♀
		2 years	5 years	9.5 years	6 years	6 years	9 years	8.5 years
		AMH 3.55 μg/L	AMH 1.69 μg/L	AMH 3.085 μg/L	AMH 0.02 μg/L	AMH 0.02 μg/L	AMH 0.025 μg/L	AMH 0.015 μg/L
		Q188R/ N314D/ L218L/ D197G	T138M/ V157I	K285N/ D98N	Q188R/ Q188R	Q188R/ Q188R	Q188R/ Q188R	Q188R/ Q188R
	0.22 μM -1.14 μM	0.51	0.56	2.9**	0.5	0.86	3.45**	1.77**
	11.7 μM -31.4 μM	18.8	15.5	36.3**	15.3	21.7	34.9**	28.4
T/ST	≤0.06	0.03	0.04	0.08**	0.03	0.0 4	0.10**	0.06

P10, P11, P13, and P14 all showed signs of ovarian dysfunction; P8, P9, and P12 did not. Core1Tn-antigen (T), sialyl-T antigen (ST), and the ratio of T/ST are presented. Glycan symbols: □: N-acetylgalactosamine (GalNAc); ○: galactose; ◆ : sialic acid (Neu5Ac). Shading and statistical significance are the same as for Table 1