Table 2.
Sociodemographic and clinical characteristics
|
Groups |
Inadequate response |
Remission |
Total |
P value |
|---|---|---|---|---|
| Number of patients, % | N = 965 (42.7%) | N = 1,295 (57.3%) | N = 2,260 | |
| Mean age, years |
61.0 (15.1) |
57.1 (16.4) |
58.8 (15.9) |
<0.001 |
| Ranges: 18–44 years |
13.7% |
24.6% |
19.9% |
<0.001 |
| 45–64 years |
46.1% |
42.6% |
44.1% |
<0.001 |
| 65–74 years |
18.1% |
13.8% |
15.7% |
<0.001 |
| > 74 years |
22.1% |
19.0% |
20.3% |
<0.001 |
| Gender, female |
76.8% |
71.9% |
74.0% |
0.009 |
| Occupational status, retired |
63.1% |
47.0% |
53.9% |
<0.001 |
| Mean number of comorbidities |
5.3 (3.5) |
4.1 (3.3) |
4.6 (3.4) |
<0.001 |
| Mean RUBs |
2.7 (0.9) |
2.4 (1.1) |
2.5 (1.1) |
<0.001 |
| RUB-1 |
17.1% |
23.4% |
20.7% |
<0.001 |
| RUB-2 |
9.3% |
18.4% |
14.5% |
<0.001 |
| RUB-3 |
59.5% |
49.5% |
53.8% |
<0.001 |
| RUB-4 |
12.3% |
7.1% |
9.3% |
<0.001 |
| RUB-5 |
1.8% |
1.5% |
1.6% |
<0,001 |
| Mean Charlson index |
0.4 (0.7) |
0.3 (0.8) |
0.4 (0.7) |
NS |
|
Associated comorbidities |
|
|
|
|
| Arterial hypertension |
39.0% |
30.6% |
34.2% |
<0.001 |
| Diabetes mellitus |
17.1% |
12.9% |
14.7% |
0.005 |
| Dyslipidemia |
49.7% |
39.1% |
43.6% |
<0.001 |
| Obesity |
22.3% |
18.7% |
20.2% |
0.035 |
| Active smoking |
22.9% |
25.9% |
24.6% |
NS |
| Alcoholism |
4.2% |
4.4% |
4.3% |
NS |
| Ischemic heart disease |
7.0% |
3.7% |
5.1% |
<0.001 |
| Cerebrovascular events |
10.6% |
7.7% |
8.9% |
0.019 |
| Cardiovascular events |
15.4% |
10.4% |
12.6% |
<0.001 |
| Organ insufficiency |
11.5% |
11.1% |
11.3% |
NS |
| Bronchial asthma. |
8.8% |
5.6% |
7.0% |
<0.001 |
| COPD |
4.2% |
3.2% |
3.6% |
NS |
| Neuropathies |
2.4% |
1.5% |
1.9% |
NS |
| Dementia (all types) |
4.9% |
3.2% |
3.9% |
0.032 |
| Organic psychosis |
3.5% |
2.9% |
3.1% |
NS |
| Malignant tumors |
10.3% |
7.1% |
8.5% |
0.008 |
| Fibromyalgia |
28.9% |
22.4% |
25.2% |
<0.001 |
| Time since MDD onset, years |
4.8 (3.8) |
3.5 (3.6) |
4.1 (3.7) |
<0.001 |
| New, incident cases (N = 738) |
23.3% |
38.7% |
32.2% |
<0.001 |
| Prevalent cases (N = 1,522) | 76.7% | 61.3% | 67.8% | <0.001 |
RUBs: resource utilization bands (morbidity burden of patients); COPD: chronic obstructive pulmonary disease; MDD: major depressive disorder; values are given as percentage or mean (standard deviation); NS: not significant.
Patients were considered to be in remission when they had a Hamilton Depression Rating Scale total score ≤ 7 points after at least 8 weeks of AD treatment in adequate doses [24,25].