Table 4.
Relationship between compliance, persistence, and referrals to mental health care. Annual follow-up
|
Groups |
Inadequate response |
Remission |
Total |
P value |
|---|---|---|---|---|
| Number of patients, % | N = 965 (42.7%) | N = 1,295 (57.3%) | N = 2,260 | |
|
Treatment compliance |
|
|
|
|
| At 6 months |
66.2% |
67.9% |
67.1% |
0.033 |
| At 12 months |
65.1% |
67.7% |
66.6% |
<0.001 |
|
Treatment persistence |
|
|
|
|
| At 6 months |
46.5% |
64.4% |
53.9% |
<0.001 |
| At 12 months |
31.8% |
53.2% |
42.7% |
<0.001 |
|
Referrals to psychiatry |
|
|
|
|
| Mean referrals (per patient) |
0.2 (0.4) |
0.1 (0.4) |
0.2 (0.4) |
0.005 |
| At 6 months (N = 293) |
4.8% |
8.2% |
13.1% |
<0.001 |
| At 12 months (N = 413) |
21.6% |
16.8% |
18.8% |
<0.001 |
| Time to referral, months |
6.4 (4.0) |
3.4 (2.4) |
4.8 (3.6) |
<0.001 |
|
Reasons for referral |
|
|
|
|
| Disease severity (N = 174) |
41.2% |
43.0% |
42.1% |
<0.001 |
| No response to treatment (N = 196) |
53.8% |
41.6% |
47.5% |
<0.001 |
| Patient decision (N = 43) | 5.0% | 15.4% | 10.4% | <0.001 |
Values given as mean (standard deviation). Treatment compliance: ratio between the numbers of tablets dispensed/prescribed. Persistence: median time without discontinuation of initial treatment or without switch to another medication, at least 8 weeks after initial prescription.