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Brain DHEA(S) metabolism. The biosynthesis of PREG and DHEA might proceed from cholesterol either through the classical pathway involving successively cytochromes P450scc and P450c17, or by an alternative pathway involving the intermediacy of sterol and/or steroid hydroperoxides. DHEA is reversibly converted to DHEAS and is the precursor of several metabolites, including sex steroid hormones.
