Fig. 1.

Simulation of the pharmacokinetic profile with 1 and 10 μg kg^–1 IV doses using the RB/QSS TMDD model (solid line), the corrected M–M model (dash line), and the original M–M model (dash-dot line). Parameters for TMDD model are listed in Table 1. M–M profiles were simulated with the following parameter values: k_el = 0.0382 h^–1, V = 68.3 ml kg^–1, k_pt = 0.0806 h^–1, k_tp = 0.0148 h^–1, V_max = 59.0795 ng kg^–1 h^–1, K_m = 0.131 ng ml^–1