Table 1.

Parameter values, WSSR and AIC obtained from fitting of the M–M model models to the simulated 100 replicates

Parameter	Description	Estimate (IQR)			Parameter bias (%)
		True value	Original M–M	Corrected M–M	Original M–M	Corrected M–M
kel (h–1)	First-order elimination	0.0382	0.00143 (0.0003, 0.00386)	0.0423 (0.0147, 0.0725)	–96.2	10.6
Vc (ml kg–1)	Volume of distribution	68.3	81.9 (78.7, 84.8)	68.3 (64.6, 72.3)	20	0.027
kcp (h–1)	Tissue distribution	0.0806	0.0979 (0.0918, 0.105)	0.078 (0.0594, 0.0962)	21.4	–3.24
kpc (h–1)	Tissue distribution	0.0148	0.0224 (0.0194, 0.0258)	0.0157 (0.0115, 0.0254)	51	5.75
kint (h–1)	Receptor internalization	0.173	N/A	0.167 (0.107, 0.223)	N/A	–3.64
kdeg (h–1)	Receptor degradation	0.173a	N/A	N/A	N/A	N/A
Keq (ng ml–1)	Dissociation constant	0.131	N/A	N/A	N/A	N/A
Rtot0 (ng ml–1)	Baseline free receptor	5	N/A	N/A	N/A	N/A
Vmax (ng kg–1 h–1)	Maximum elimination rate	59.1b	144.5 (122.2, 157.7)	56.9 (43.8, 72.1)	145	–3.7
Km (ng ml–1)	Michaelis constant	0.131c	1.06 (0.616, 1.3)	0.29 (0.0685, 0.664)	711	121
WSSR	Weighted sum of squared residuals	N/A	0.567 (0.436, 0.748)	0.243 (0.173, 0.321)	N/A	N/A
AIC	Akaike information criterion	N/A	2.63 (–2.11, 7.07)	–10.0 (–15.8, –5.32)	N/A	N/A

The median value and interquartile range were calculated and reported. Parameter bias was calculated based on median values IQR interquartile range, N/A not applicable

^aFixed at k_int value

^bCalculated as R_tot0k_intV

^cSame to K_D