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. 2012 Aug 23;7(8):e43646. doi: 10.1371/journal.pone.0043646

Figure 6. Roles of XB130 in cell cycle progression and survival of cancer.

Figure 6

XB130 specifically binds p85α subunit of PI3K, which subsequently activate Akt. Akt plays an essential role in cell proliferation and survival. Down-regulation of XB130 with siRNA affected multiple molecules down-stream of Akt. This suggests that XB130 is an important regulator in PI3K/Akt related cancer cell proliferation and survival.