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. 2012 Aug 23;8(8):e1002876. doi: 10.1371/journal.ppat.1002876

Figure 1. Structure based sequence alignment of IL18 binding proteins.

Figure 1

Structure based sequence alignment of various IL18BPs was created using the crystal structure of YLDV-IL18BP as the template. Lettering and numbering above alignment correspond to YLDV-IL18BP topology and numbering scheme. Colored stars above residues indicate the three binding sites on IL18 with which they interact, red: site A, orange: site B, cyan: site C. Solid black circles above residues indicate resides involved in homo-dimerization. The two intra-chain disulfide bonds are indicated with the green letters. The cysteine residue forming the unique inter-chain disulfide bond is indicated with a pink triangle. The sequence alignment was performed with the FATCAT server [44] and ClustalX [45], and the figure was created with ESPript [46].