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. 2012 Aug 23;8(8):e1002876. doi: 10.1371/journal.ppat.1002876

Figure 3. Key interactions of the YLDV-IL18BP homo-dimer.

Figure 3

A). YLDV-IL18BP dimerizes back-to-back, abutting on one edge of the Ig-fold through extensive hydrophobic interactions. The secondary structures are labeled. The inter-chain C132-C132 SS bond is shown as orange spheres. B). The E42 from one protomer appears to be protonated, forming a hydrogen bond with E42 from the other protomer. E42 also forms both intra-chain and inter-chain hydrogen bonds with R44. E42 and R44 residues are shown as sticks. The 2mFo-DFc electron density map is shown in blue. C). Hydrophobic stacking of residues H30 and P32 of one YLDV-IL18BP protomer with their counterparts of the other protomer. D) Residue V33 of one protomer is inserted into the hydrophobic platform comprised of I29, V31, V124, and I129 of the second protomer.