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. 2012 Aug 23;8(8):e1002890. doi: 10.1371/journal.ppat.1002890

Figure 4. Relationship between the extent of vaccine strain replication and ADCC activity.

Figure 4

The extent of SIVmac239Δnef or SIVmac239Δnef/E543-3env replication was estimated from the area under the curve (AUC) of log10-transformed vaccine strain viral loads over weeks 0 through 21 or 22, and compared to ADCC activity at week 21 or 22. Vaccine strain viral load AUC values were correlated with 50% ADCC titers (A) against Env-matched (RS = 0.68, P<0.0001) and Env-mismatched (RS = 0.55, P = 0.006) SIV strains, and also with AUC values for ADCC activity (B) against Env-matched (RS = 0.64, P<0.0001) and Env-mismatched (RS = 0.42, P = 0.0421) SIV strains. Linear regression lines are drawn.