Table 1.
Description of study population
| Colon | Rectal | ||||
|---|---|---|---|---|---|
| Control | Case | Control | Case | ||
| n (%) | n (%) | n (%) | n (%) | ||
| Age | 30–39 | 40 (2.04) | 23 (1.48) | 21 (2.19) | 19 (2.52) |
| 40–49 | 128 (6.54) | 102 (6.56) | 101 (10.53) | 96 (12.73) | |
| 50–59 | 326 (16.67) | 290 (18.65) | 243 (25.34) | 196 (25.99) | |
| 60–69 | 673 (34.41) | 538 (34.60) | 329 (34.31) | 250 (33.16) | |
| 70–79 | 789 (40.34) | 602 (38.71) | 265 (27.63) | 193 (25.60) | |
| Center | Utah | 378 (19.33) | 249 (16.01) | 365 (38.06) | 274 (36.34) |
| KPMCP | 787 (40.24) | 744 (47.85) | 594 (61.94) | 480 (63.66) | |
| Minnesota | 791 (40.44) | 562 (36.14) | 0 (0) | 0 (0) | |
| Race/Ethnicity | NHW | 1828 (93.46) | 1428 (91.83) | 824 (85.92) | 625 (82.89) |
| Hispanics | 75 (3.83) | 59 (3.79) | 63 (6.57) | 61 (8.09) | |
| Black | 53 (2.71) | 68 (4.37) | 43 (4.48) | 29 (3.85) | |
| Asian | 0 | 0 | 29 (3.02) | 39 (5.17) | |
| Sex | Male | 1047 (53.53) | 870 (55.95) | 541 (56.41) | 451 (59.81) |
| Female | 909 (46.47) | 685 (44.05) | 418 (43.59) | 303 (40.19) | |
| Location | SNP | MAF1 | HWE2 | ||
| TERT | 5p15.33 | rs2736118 | 0.27 | 0.27 | |
| rs4246742 | 0.15 | 0.15 | |||
| rs10069690 | 0.25 | 0.25 | |||
| rs2242652 | 0.19 | 0.19 | |||
| rs2736100 | 0.5 | 0.5 | |||
| rs2853676 | 0.26 | 0.26 | |||
| TERT-CLPTM1L | rs2853668 | 0.26 | <0.01 | ||
1
Minor Allele Frequency (MAF) in control population
2
Hardy Weinberg Equilibrium (HWE)