Table 2.
Cohort Host and Viral Risk Factors and Abstinence, According to Pretreatment Alcohol Intake
| Risk Factors | Pretreatment Alcohol Intake | Totals (N=253) |
||||
|---|---|---|---|---|---|---|
| Less than 100 kg (N=93)1 |
100 to 350 kg (N=67) |
351 to 1000 kg (N=54) |
Over 1000 kg (N=39) |
p | ||
| Age (Mean ± SD) | 50.2 (7.3) | 49.6 (6.5) | 50.2 (5.9) | 49.2 (9.5) | 49.9 (7.2) | NS |
| Gender (% Male) | 22.2% | 38.2% | 59.0% | 85.2% | 59.9% | <.001 |
| Race/Ethnicity (% non-Hispanic White) | 76.6% | 89.6% | 79.6% | 71.8% | 79.9% | .106 |
| Pretreatment Viral Load (% ≥ 600,000 IU /ml) | 54.8% | 58.2% | 48.1% | 59.0% | 54.9% | NS |
| Genotype (% 1, 4 or 6) | 51.6% | 53.0% | 53.7% | 64.1% | 54.4% | NS |
| Advanced Fibrosis (% Positive) (N=197) | 38.6% | 31.4% | 41.5% | 33.3% | 35.5% | NS |
| Failure to meet 80-80-80 Criteria | 11% | 7.7% | 0% | 5.1% | 6.9% | .086 |
| Treatment Discontinuation (Overall %) | 17.4% | 9.1% | 5.6% | 20.5% | 13.1% | .073 |
| For Adverse Events (%) | 15.2% | 9.1% | 3.7% | 12.8% | 10.8% | NS |
| For Non-Compliance (%) | 1.1% | 0% | 1.9% | 7.7% | 2.0% | .042 |
| For Unrelated Illness (1%) | 1.1% | 0% | 0% | 0% | .4% | NS |
| Duration of Pretreatment Abstention | ||||||
| <6 Months | 25.0% | 35.8% | 35.2% | 15.4% | 28.8% | .054 |
| 6 Months – 2 Years | 9.2% | 14.9% | 11.1% | 20.5% | 13.1% | |
| 2 – 10 Years | 22.4% | 22.4% | 22.2% | 41.1% | 25.4% | |
| 10+ Years | 43.4% | 26.9% | 31.5% | 23.2% | 32.6% | |
1
Includes 18 patients who said they never drank regularly; 14 drank irregularly; 4 never drank or had fewer than 12 drinks in a 12-month period. Duration of abstention is missing for these 18 patients.
*
The probability of significantly different ages related to pretreatment alcohol intake is based on analysis of variance; elsewhere significance levels are based on 2-sided χ2 tests for categorical variables.