Table 6.
Fold changes in gene expression in colon tissues of conventional rats fed RS for 28 daysa
| Gene | Description | FCc | FDRd |
|---|---|---|---|
| Gsta2 | Glutathione-S-transferase, alpha type 2 | 2.6 | 0.001 |
| Ela1 | Elastase 1, pancreatic | 2.5 | 0.033 |
| Cdig1l | Cadmium-inducible gene 1L | 1.7 | 0.004 |
| RGD1565715 | Low-density lipoprotein receptor-related protein binding protein (predicted) | −1.7 | 0.032 |
| LOC683313 | Keratin complex 2, basic, gene 6a, transcript variant 2 | 1.7 | 0.048 |
| Wbscr14 | Williams-Beuren syndrome chromosome region 14 homolog | 1.6 | 0.001 |
| LOC680102 | MAbb-21-like 2 (LOC680102) (predicted) | −1.6 | 0.022 |
| Calcb | Calcitonin-related polypeptide, beta | −1.6 | 0.047 |
| Tac1 | Tachykinin 1 | −1.5 | 0.008 |
a
Changes in differentially expressed genes with known functions between conventionally raised rats fed BD or RS 5% for 28 days (n = 6).
b
MAb, monoclonal antibody.
c
FC, fold change in expression between treatments, with a positive value indicating higher expression in RS-fed rats and a negative value indicating higher expression in BD-fed rats.
d
FDR, false-discovery rate, a multiple-testing adjustment of P values determined by a linear model of microarray analysis (limma).