Table 2. Multivariate analysis related to survival using Cox regression.

Variables	OR	95% CI		P
Age	0.98	0.95-1.01		0.24
Female® Male	- 1.04	- 0.37-2.92		- 0.92
Non-smoker® Smoker	- 1.41	- 0.50-3.93		- 0.51
Squamous® Adenocarcinoma	- 1.40	- 0.78-2.51		- 0.25
Tumor diameter	1.17	1.01-1.35		0.031*
Tumor stage     1A®     1B     2A     2B     3A	- 2.23 4.39 1.49 6.82	- 0.28-17.3 0.56-34.1 0.17-12.9 0.89-52.1		- 0.44 0.15 0.71 0.06
N0® N1 N2	- 1.47 2.79	- 0.74-2.94 1.36-5.74		- 0.26 0.005*
Differentiation     Poor®     Moderate     Well	- 0.41 0.73	- 0.16-1.06 0.32-1.67		- 0.06 0.46
Lobectomy® Pneumonectomy	- 1.57	- 0.75-3.26		- 0.22
Adjuvant therapy     Given®     Not given	- 0.66	- 0.37-1,20		- 0.17
Nuclear topo2α     Negative®     Positive	- 1.24	- 0.69-2.22		- 0.46
Cytoplasmic topo2α     Negative®     +     ++     +++	- 1.04 1.97 1.28	- 0.49-1.22 0.86-4.47 0.57-2.90		- 0.90 0.10 0.54

®Reference category, *Statistically significant.