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. 2012 Aug;4(4):390–397. doi: 10.3978/j.issn.2072-1439.2012.07.12

Figure 2.

Figure 2

A model for TOP1-mediated cytotoxicity and radiation sensitization. In this model, the drug-trapped TOP1 cleavable complex initiates TOP1-mediated DNA damage by “interacting” with replication fork during DNA synthesis. Double strand DNA breaks, replication fork arrest and an aborted “cleaved” TOP1-DNA complex can be generated. Based on the dependence on NHEJ double-strand DNA repair, current data indicate dissociation between the pathways lead to TOP1-mediated cytotoxicity and TOP1-mediated radiation.