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. 2012 Sep;13(6):489–497. doi: 10.2174/138920212802510448

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©2012 Bentham Science Publishers

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (1). Working hypothesis of the link between CNS stress and risks of neuropsychiatric diseases. — We hypothesize that there are common early stress response mechanisms (gate keepers) in the CNS that are induced after exposures to a broad variety of environmental stress/insults, and that these mechanisms are associated with increased risks for a broad range of neuropsychiatric diseases.