Table 2.
Knowledgebase Comparisons Identified Several Low-Dose Cognition-Related CNS Pathways that are Similarly Affected in the Aging Human Brain and in the Brain of Alzheimer’s Disease Patients
| Pathway | Mouse | Human | |
|---|---|---|---|
| Low-Dose Irradiation Brain* | Aging** | Alzheimer's Disease*** | |
| Integrin Signaling | ⇑ | ⇑ | ⇑ |
| Synaptic Long Term Depression | ⇓ | ⇓ | ⇓ |
| Synaptic Long Term Potentiation | ⇓ | ⇓ | ⇓ |
| cAMP Mediated Signaling | ⇓ | ⇓ | ⇓ |
| G-Protein Coupled Receptor Signaling | ⇓ | ⇓ | ⇓ |
| Glutamate Receptor Signaling | ⇓ | ⇓ | ⇓ |
| Actin Cytoskeleton Signaling | ⇔ | ⇔ | ⇔ |
| Axonal Guidance Signaling | ⇔ | ⇔ | ⇔ |
| ERK/MAPK Signaling | ⇔ | ⇔ | ⇔ |
*
Brain tissue from mice that received 10 cGy of whole-body radiation (unique low-dose genes)[28].
**
Brain tissue from aging human [36].
***
Hippocampal brain tissue from Alzheimer’s disease patients [37].
⇑
Component genes of pathway were generally upregulated.
⇓
Component genes of pathway were generally down regulated.
⇔
Component genes of pathway modulated in variable directions.