Table 1.

Peptides Selected for In vivo Imaging

Name	Sequence	Description	D/L	Results	Reference
none	DWGKGGRWRLWPGASGKTEA and PGRSPFTGKKLFNQEFSQDQ	Selected by phage display	L	Binds amyloid form of Aβ40, labels amyloid plaques in AD brains slices, discussed as carrier protein for plaque treatment and in vivo imaging	Kang et al., 2003 [40]
D1/ ACI-80	ACI-80: QSHYRHISPAQV	Selected by mirror image phage display	D	Aggregate specific, stains human Aβ plaques selectively, stains plaques in mice ex vivo	Wiesehan et al., 2003 [46] Van Groen et al., 2009 [47]
none	C-IPLPFYN-C / C-FRHMTEQ-C	Selected by phage display	L	Kd for Aβ42 in micromolar range, specific interaction with plaques on brain sections (immunochemistry), encouraging preliminary MRI in vivo study in mice after opening of bbb by mannitol	Larbanoix et al., 2008 [48]
Pep1 Pep2	LIAIMA IFALMG	Selected by phage display, library based on Aβ sequence	L	Kd for Aβ42 in micromolar range, specific interaction with plaques in human brain sections (immunochemistry), inhibit Aβ aggregation	Larbanoix et al., 2011 [49]

bbb: blood brain barrier. D/L: describes peptide conformation.