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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Adv Skin Wound Care. 2012 Aug;25(8):349–370. doi: 10.1097/01.ASW.0000418541.31366.a3

Table 2.

GENE DELIVERY INTO THE WOUND BED

DNA Carriers Delivery Mode Growth Factors Tested Outcome
Plasmids “Gene gun” PDGF Increased wound tensile strength164
EGF Increased epithelialization, granulation tissue165
Injection via microneedles EGF Increase in transgene expression, effects on wound healing are not reported167
Electroporation FGF-7 Increased wound epithelialization169
VEGF Improved skin flap healing170
Liposomal formulations FGF-1 Accelerated wound closure171
IGF/KGF Increased collagen deposition, VEGF production, improved healing173
Viral delivery
Adenoviruses Topical application VEGF Improved angiogenesis and wound healing174
“Gene gun” Erb3 + topical EGF Improved epithelialization64
Injection via microneedles VEGF No effect on wound healing168
Adeno-associated viruses Intradermal injection VEGF Increased angiogenesis and rate of wound healing176,177
Retroviruses Ex vivo cell transfection followed by transplantation into animals PDGF Increase epithelial thickness and angiogeneis187

Abbreviations: EGF, epidermal growth factor; FGF, fibroblast growth factor; KGF, keratinocyte growth factor; PDGF, platelet-derived growth factor; VEGF, vascular endothelial growth factor.