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. 2012 Aug 6;109(34):13823–13828. doi: 10.1073/pnas.1208075109

Fig. 4.

Fig. 4.

SP_1119 is immunogenic during S. pneumoniae colonization. (A) Western blot of purified recombinant SP_1119 or P5CDH incubated with mouse sera before (pre) and after (after) pneumococcal (TIGR4) or sham (PBS) colonization. (B) Quantification by ELISA of the increase in serum IgG titers to SP_1119 after pneumococcal (TIGR4) or sham (PBS) colonization. n = 10 mice per group. (C) Correlation between fold increase in serum IgG titers to SP_1119 and P5CDH in mice colonized with S. pneumoniae TIGR4 (closed squares) or S. pneumoniae TIGR4sp_1119 (open diamonds). (D) Detection of P5CDH (arrow) by specific anti-P5CDH sera in a Western blot of whole-cell lysates of the S. aureus strains indicated. MSSA, methicillin-sensitive S. aureus; MRSA, methicillin-resistant S. aureus.