Fig. 1.
Correlation of gene expression level with incubation time. Data are taken from GeneChip Mouse Genome 430 2.0 arrays (Affymetrix) hybridized with cRNA prepared from the whole brains from each of five mouse inbred lines: NZW/OlaHsd, SJL/OlaHsd, FVB/NHsd, SWR/OlaHsd, and C57BL/6JOlaHsd (n = 5 per strain). Mean incubation time of each mouse strain inoculated with the Chandler/RML prion strain is measured in days and is shown on the x axis. Mean expression level for each probe is represented on the y axis (±SD). Expression level data are shown following scaling and normalization using the robust multichip average (RMA) method. R2 represents the square of the Pearson product moment correlation coefficient. (A) Fkbp9, (B) Cbx1, (C) Gpr19, (D) AK013823, and (E) Hspa13 (Stch).