Table 1.
Differential expression of HDACs in starvation vs. control conditions
| Symbol | Av control* | Av starved* | t test† | Ctrl/Strv | +/−Y‡ | +/−M/C‡ | M/C vs. Y§ |
| HDAC1 | 12,497 ± 20% | 12,609 ± 27% | 0.97 | 0.99 | / | / | / |
| HDAC2 | 8,913 ± 9% | 9,190 ± 22% | 0.74 | 0.97 | / | / | / |
| HDAC3 | 2,425 ± 16% | 2,360 ± 12% | 0.68 | 1.03 | / | / | / |
| HDAC4 | 1,476 ± 26% | 341 ± 69% | 0.03 | 4.33 | 2.12 | 13.13 | 6.20 |
| HDAC6 | 587 ± 12% | 420 ± 5% | 0.01 | 1.40 | 1.39 | 1.41 | 1.01 |
| HDAC8 | 545 ± 7% | 502 ± 18% | 0.46 | 1.09 | / | / | / |
| SIRT1 | 1,516 ± 10% | 1,706 ± 34% | 0.49 | 0.89 | / | / | / |
| SIRT2 #1 | 254 ± 6% | 258 ± 9% | 0.80 | 0.98 | / | / | / |
| SIRT2 #2 | 301 ± 7% | 305 ± 10% | 0.85 | 0.98 | / | / | / |
| SIRT4 | 435 ± 30% | 931 ± 21% | 0.01 | 0.47 | 0.45 | 0.48 | 1.06 |
| SIRT5 #1 | 372 ± 11% | 281 ± 23% | 0.15 | 1.32 | / | / | / |
| SIRT5 #2 | 1,358 ± 9% | 666 ± 19% | 0.01 | 2.04 | 2.58 | 1.65 | 0.64 |
| SIRT7 | 470 ± 11% | 870 ± 33% | 0.09 | 0.54 | / | / | / |
Av, average; Ctrl, control; SIRT, sirtuin; Strv, starved; #, arbitrary number assigned to distinguish multiple probes referring to the same gene; /, not calculated.
*Average ± SD of signal values generated by Illumina microarrays for control or starved HeLa and HeLa-OA1myc cells.
†Paired two-tailed Student t test of starved vs. control group. Bold numbers indicate significant values and correspond to genes that are differentially expressed in the two conditions.
‡Ratio of mean signal values in control group (+) vs. starved group (−) for either Y or M/C deprivation conditions.
§Ratio of M/C vs. Y differential expression.