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. 2012 Aug 6;109(34):13728–13732. doi: 10.1073/pnas.1202882109

Table 1.

Myc:Igh translocations

Transgenic line Primary tumor Genetic background Translocations Other
995 Chr 4 at 98.3 of 154.3 Mb VDJ centromere proximal 4816 C57BL/6, Bcl-xL 4;15 Myc-Sμ (cloning), secretes IgA
1022 C57BL/6, Bcl-xL 4;15
820 Chr 7 at 122 of 145 Mb VDJ centromere proximal 74149 Mixed, Bcl-xL* 7;15
74150 Mixed, Bcl-xL 7;15
74160 Mixed, Bcl-xL 7;15 and 12;18 Secretes IgA
74162 Mixed, Bcl-xL 12;15
74163 Mixed, Bcl-xL 7;15 Secretes IgA, Pvt1-Sα (cloning)
74219 Mixed, Bcl-xL 7;15 and 6;13
74220 Mixed, Bcl-xL 12;15
74223 Mixed, Bcl-xL 7;15
74997 Mixed, Bcl-xL 12;15
75000 Mixed, Bcl-xL 12;15
75001 Mixed, Bcl-xL 7;15 Chr 4 insertion into 7;15
75002 Mixed, Bcl-xL 7;15 Secretes IgA and IgG2a
75002 Mixed, Bcl-xL 12;15
75004 Mixed, Bcl-xL 12;15
336 Chr 14 near centromere orientation unknown 78286 Mixed, Bcl-xL* 14:15
79130 Mixed, Bcl-xL 14?;15, 15;18, and 1;4 Myc-Sγ2a (cloning)
79134 Mixed, Bcl-xL 14;15
79710 Mixed, Bcl-xL 14;15
79711 Mixed, Bcl-xL 14;15
79716 Mixed, Bcl-xL 14;15 and 9;16
80635 Mixed, Bcl-xL 14;15
80639 Mixed, Bcl-xL 12;15
80648 Mixed, Bcl-xL 14;15
82028 Mixed, Bcl-xL 12;15
82043 Mixed, Bcl-xL 14;15
82048 Mixed, Bcl-xL 12;15
82181 Mixed, Bcl-xL 14;15
83353 Mixed, Bcl-xL 12;15
556 Chr 17 at 89.6 of 95.2 Mb VDJ centromere distal 1854 BALB/cAn 15;17 Interphase, Myc-Sα (cloning)
2731 C57BL/6, Bcl-xL not 15;17 Interphase
234 Chr 1 near telomere 78709 Mixed, bclxL* 12;15
79145 Mixed, bclxL 12;15
80616 Mixed, Bcl-xL 1;15 and 6;13
80621 Mixed, Bcl-xL 12;15
83366 Mixed, Bcl-xL 12;15

*In addition, lines 820, 336, and 234 had a B1-8 VH recombined into one of the endogenous Igh loci (41).

The ascites in mouse no. 75002 included two tumor clones.

The ambiguity concerning the translocation in tumor no. 79130 is detailed in the data and legend of Fig. S2.