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Aggregation of p53 Y220C with or without zinc. N.Zn2+.L, native holo-Y220C bound to ligand; N.Zn2+, native holo-Y220C; D.Zn2+, denatured holo-Y220C; I, aggregation-competent intermediate; apo-N.L, native apo-Y220C bound to ligand; apo-N, native apo-Y220C.
