Fig. 5.

Increased mast cell and red blood cell numbers in Kit^{V558∆;T669I/+} mice. (A) Representative photograph of alopecia of truncal hair in 4-wk-old Kit^{V558Δ;T669I/+} mice. (B) Representative photographs of wild-type hind-paw in 3-mo-old wild-type mice and “red paw” phenotype in 3-mo-old Kit^{V558Δ;T669I/+} mice. (C) Increased mast cell numbers in dorsal skin of Kit^{V558Δ;T669I/+} (GTK) mice in comparison with wild-type and Kit^V558Δ/+ mice (n = 3). (D) BM cellularity of Kit^{V558Δ;T669I/+} mice measured as total nucleated cells per bone is similar to that in wild-type mice. Spleen cellularity is significantly increased in the mutants compared with wild-type mice. n = 6. (E) Time course of hematocrit and (F) MCV showing development of erythrocytosis and microcytosis phenotype in Kit^{V558Δ;T669I/+} mice (red curves) in and wild-type mice (black curves). n = 5–17. Error bars indicate means ± SD.