Figure 1. Patients with early arthritis who were homozygous for the minor rs7574865 allele of STAT4 exhibited stronger disease activity during the follow-up.

The data are categorized according to the rs7574865 genotype of STAT4 (upper panel), the rs2476601 genotype of PTPN22 (middle panel), and the number of copies of the shared epitope (SE; lower panel). Data represent the interquartile range (p75, upper edge of the box; p25, lower edge; p50, midline), p95 (line above the box) and p5 (line below the box) of the DAS28 adjusted for gender and age (aDAS28). Dots represent outliers.