Table 3. Effect of the presence of the shared epitope and the minor rs7574865 allele of STAT4 or rs2476601 in PTPN22 on the level of disease activity.
| β Coeff. (95% CI) | p value | |
| Age (years) | ||
| <45 | Ref. | |
| 45–65 | 0.64 (0.42–0.86) | <0.001 |
| >65 | 0.70 (0.47–0.94) | <0.001 |
| Gender | ||
| Man | Ref. | |
| Woman | 0.65 (0.44–0.86) | <0.001 |
| Diagnosis | ||
| RA | Ref. | |
| UA | −0.51 (−0.79– −0.23) | <0.001 |
| Positive ACPA | 0.32 (0.13–0.51) | 0.001 |
| Shared epitope | NS | NS |
| STAT4 (rs7574865) | ||
| GG | Ref. | |
| GT | −0.02 (−0.21–0.16) | 0.785 |
| TT | 0.56 (0.01–0.83) | 0.002 |
| PTPN22 (rs2476601) | ||
| CC | Ref | |
| CT | −0.29 (−0.54– −0.04) | 0.025 |
| TT | −0.55 (−1.44–0.33) | 0.221 |
| Hospital | ||
| Center 1 | Ref. | |
| Center 2 | −0.25 (−0.45– −0.06) | 0.01 |
| Cutpoints | ||
| Remission/Low disease activity | −0.10 (−0.40–0.20) | – |
| Low/Moderate disease activity | 0.55 (0.24–0.85) | – |
| Moderate/High disease activity | 2.34 (2.02–2.66) | – |
DAS28, 28-joint Disease Activity Score; HAQ, Health Assessment Questionnaire; Coeff., coefficient; Ref., reference; RA, rheumatoid arthritis; UA, undifferentiated arthritis; ACPA, anti-citrullinated peptide antibodies; NI, not included; NS, non-significant.