Table 1. miRNAs with relevance in autophagy.
| miRNAs | Chromosome location | Disease relevance | Targets relevant to autophagy | Function | References |
|---|---|---|---|---|---|
| MIR30A |
6q13 |
Targets B-Myb oncogene during cellular senescence |
BECN1 |
Regulation of autophagic response to rapamycin in cancer cells |
16, 19 |
| MIR206 |
6p12.2 |
Blocks the growth of human rhabdomyosarcoma and breast cancer cells |
KAT6A (MYST3) |
Modulation of histone acetylation |
23, 27, 28, 35 |
| miR-9-3p |
1q22, 5q14.3, 15q26.1 |
Downregulated in the prefrontal cortex of schizophrenic subjects; contributes to tumor metastasis |
HDAC4 and HDAC5 |
Modulation of histone acetylation |
29, 33, 35 |
| MIR101 |
1p31.3, 9p24.1 |
Locus is lost in clinically localized prostate cancers or metastatic prostate cancers |
RAB5A, ATG4D and STMN1 |
Sensitizes breast cancer cells to 4-OHT-mediated cell death. |
43, 45 |
| MIR17,20,93 and 106 |
13q31.3, 7q22 |
Elevated in B-cell lymphoma and modulate tumor formation |
SQSTM1 (p62) |
Promote hematopoietic cell expansion |
56, 58 |
| MIR204 |
9q21.12 |
Downregulated in the NCI60 tumor cell lines; Involved in pulmonary arterial hypertension |
MAP1LC3 |
Regulation of cardiomyocyte autophagy induced by hypoxia-reoxygenation |
62–64 |
| MIR196 | 17q21.32, 12q13.13, 7p15.2 |
Potential roles in melanoma and acute leukemia | IRGM | Deregulation of IRGM-dependent xenophagy | 67, 68, 73 |