Figure 4. Differential Activation of MAPK in the Cardiac Remodeling of T4-treated Mice.

Western blot analyses of total and phospho-ERK1/2 (A), total and phospho-JNK (B), and total and phospho-p38 (C) in the mice hearts. * is significant change compared to untreated WT mice, ** is significant change compared to T4-treated and untreated WT mice, # is significant change compared to untreated transgenic mice, + is significant change compared to T4-treated transgenic mice, ∧ is significant change compared to T4-supplemented transgenic mice that pre-treated with carvedilol (n = 8/group).