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. 2012 Aug 24;7(8):e43471. doi: 10.1371/journal.pone.0043471

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© 2012 Venet et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Evaluation by NGS of the diversity of synthetic CDRH3 from SnA, SnA-R3 and SiB (one million sequences were analyzed for each) and their repartition into human frameworks. (A) The percentage of CDRH3 in function of their frequency is represented by a color code. The values on the histograms are the number of unique CDRH3 corresponding to each section. (B) Frameworks repartition by family VH1, 3 or 5 in each library and in the selection round SnA-R3. Undetermined are sequences for which no framework could be attributed due to frame shifts.