Cells were grown without (m) or with the addition of various phenolic compounds ranging from 10 nM to 1 mM for 1 h in the case of cells with pRLuc42R. The activities were shown as the ratio of induced to non-induced activities. The four sets of data (pRLuc42R, pRLuc, pRLuc140p143R and pRLuc113p116R) are the average of three independent experiments. (A) 2,4-dimethylphenol (B) 2,4,6-trichlorophenol (C) 2-chlorophenol (D) 2-nitrophenol (E) 2, 4-dichlorophenol (F) 4-nitrophenol, (G) o-cresol, (H) Xylene. **p<0.01, ***p<0.001 compared with normalized luciferase activity of pRLuc; #p<0.05, ###p<0.001 compared with normalized luciferase activity of pRLuc113p116R; one-way ANOVA followed by Newman-Keuls Multiple Comparison Test.