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. Author manuscript; available in PMC: 2013 Aug 30.
Published in final edited form as: Neurosci Lett. 2012 Jul 20;524(2):111–115. doi: 10.1016/j.neulet.2012.07.018

Figure 2.

Figure 2

Effects of local treatment of U50, 488 on CFA-induced mechanical hyperalgesia. On day 3 of CFA injection, changes in mechanical thresholds after local U50, 488 treatment were measured for 180 minutes in male (A) and female (B) rats. The drug was administered 5 minutes after pre-treatment measurement of mechanical threshold. * indicates significant groups effect compared to PBS at p < 0.05. (C) Direct comparisons of percent changes in mechanical thresholds between male and female rats following PBS or drug treatment. * and + indicate significant group and time effect, respectively. Each group consisted of n=6.