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. Author manuscript; available in PMC: 2013 Aug 30.
Published in final edited form as: Neurosci Lett. 2012 Jul 20;524(2):111–115. doi: 10.1016/j.neulet.2012.07.018

Figure 3.

Figure 3

Local and receptor mediated effects of U50, 488. On day 3 of CFA injection, U50, 488 injected into the hindpaw contralateral to the CFA-inflamed paw had no effect on mechanical thresholds in either males or females (A, B). On day 3 of CFA injection, changes in mechanical thresholds after local U50, 488 treatment with nor-BNI in the same paw were measured in male and female rats (C). The nor-BNI was administered 5 minutes after the pre-treatment measurement of mechanical threshold, followed by U50, 488. *, + indicates significant group and time effect, respectively. Each group consisted of n=6.