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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 20;63(6):966–973. doi: 10.1016/j.neuropharm.2012.06.065

Figure 2.

Figure 2

The depressant effect of nicotine on activity and body temperature is dependent upon the time of day. The effect of nicotine at each time point for activity (A) and body temperature (B) was determined by subtracting the nicotine response from the saline response (n was between 4–9 animals per time point per sex). A main effect of time of day on sensitivity to the depressant effects of nicotine on activity (p < 1 × 10−4) and body temperature (p < 1 × 10−5) was observed. In general, maximal sensitivity to nicotine for both measures occurred during the light phase and minimal sensitivity occurred during the dark phase of the light cycle. Data are represented as mean ± SEM. White bar represents time frame of lights on and black bar represents time frame of lights off.