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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 20;63(6):966–973. doi: 10.1016/j.neuropharm.2012.06.065

Figure 3.

Figure 3

Time of day effects of nicotine are dose dependent. Male C3H/Ibg were tested for the effect of 3 different doses of nicotine on activity and body temperature at ZT9 and ZT21 (n was between 5–13 animals per dose per time point). Time of day dependent effects of nicotine on activity were only seen at the 1.0 mg/kg dose (p < 0.05) while significant time of day effects of nicotine on body temperature were observed at the 0.5 (p < 0.01) and 1.0 mg/kg nicotine doses (p < 0.01). The time of day-dependent effect of a 1.5 mg/kg dose of nicotine on body temperature approached significance (p = 0.054). Data are represented as mean ± SEM. * = p < 0.05; ** = p < 0.01.