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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 20;63(6):966–973. doi: 10.1016/j.neuropharm.2012.06.065

Figure 4.

Figure 4

Melatonin deficient mouse strains do not differ in sensitivity to the effects of nicotine between ZT9 and ZT21. C57BL/6J male mice exhibited similar sensitivity to the effects of nicotine on activity (A) and body temperature (B) at ZT9 and ZT21 when tested at either 0.25 (n = 5 per time point) or 0.5 mg/kg (n = 12–13 per time point) nicotine. Similarly, 0.5 mg/kg (n = 5–8 per time point) and 1.0 mg/kg (n = 12–14 per time point) doses of nicotine did not have zeitgeber time-dependent effects on activity (C) or body temperature (D) in DBA/2J male mice. Data are represented as mean ± SEM.