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Melatonin receptors are essential for reduced sensitivity to nicotine at ZT21. C3H genetic background mice that possess homozygous null mutations for the melatonin receptors Mtnr1a and Mtnr1b are not differentially sensitive to the effects of 1 mg/kg nicotine on activity (A) or body temperature (B) at ZT9 and ZT21 (n = 24 per time point).
