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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 20;63(6):966–973. doi: 10.1016/j.neuropharm.2012.06.065

TABLE 1.

Binding data for [125I]-α-bungarotoxin (BTX) and [125I] epibatidine (Epi) across 6 times points and 4 brain regions in C3H/Ibg and DBA/2 mice. Data were normalized to ZT1 (7 AM) and are represented as mean ± SEM. Significant effects of time of day were only observed for BTX binding in the hypothalamus of C3H mice (see figure 6 for details).

Brain Region
Cortex Hippocampus Hypothalamus Striatum
Time Point (ZT) Time Point (ZT) Time Point (ZT) Time Point (ZT)
Strain Ligancl 1 5 9 13 17 21 1 5 9 13 17 21 1 5 9 13 17 21 1 5 9 13 17 21
C3H BTX 1.00 (0.06) 0.95 (0.09) 1.14 (0.07) 1.18 (0.13) 0.91 (0.06) 1.11 (0.08) 1.00 (0.13) 0.74 (0.13) 1.10 (0.09) 1.20 (0.14) 1.19 (0.11) 0.98 (0.15) 1.00 (0.10) 1.25 (0.15) 1.45 (0.12) 1.41 (0.19) 1.06 (0.11) 0.92 (0.11) 1.00 (0.07) 1.05 (0.07) 1.06 (0.10) 1.19 (0.06) 1.15 (0.09) 1.10 (0.18)
Epi 1.00 (0.12) 1.08 (0.07) 0.77 (0.15) 1.02 (0.04) 1.13 (0.07) 0.84 (0.09) 1.00 (0.09) 0.85 (0.08) 0.83 (0.09) 0.91 (0.11) 0.91 (0.10) 0.78 (0.11) 1.00 (0.09) 0.97 (0.09) 0.94 (0.09) 0.93 (0.10) 0.97 (0.10) 0.66 (0.08) 1.00 (0.05) 0.99 (0.06) 0.80 (0.16) 0.92 (0.16) 1.06 (0.07) 1.16 (0.16)
DBA BTX 1.00 (0.05) 0.99 (0.09) 1.02 (0.05) 0.93 (0.11) 1.19 (0.12) 0.99 (0.08) 1.00 (0.16) 0.91 (0.08) 0.93 (0.10) 1.02 (0.15) 0.86 (0.11) 0.95 (0.14) 1.00 (0.08) 0.91 (0.10) 0.96 (0.06) 0.92 (0.16) 0.89 (0.07) 0.82 (0.07) 1.00 (0.09) 1.08 (0.09) 0.77 (0.04) 1.14 (0.11) 1.04 (0.09) 1.05 (0.06)
Epi 1.00 (0.05) 1.25 (0.09) 1.18 (0.08) 1.14 (0.07) 1.02 (0.04) 1.05 (0.05) 1.00 (0.06) 1.23 (0.05) 1.01 (0.08) 1.22 (0.30) 1.33 (0.16) 0.92 (0.13) 1.00 (0.13) 0.86 (0.14) 0.80 (0.06) 0.89 (0.13) 0.80 (0.05) 0.93 (0.09) 1.00 (0.06) 1.05 (0.07) 0.91 (0.10) 1.01 (0.08) 1.00 (0.09) 0.94 (0.05)