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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Trends Immunol. 2012 Jul 18;33(9):442–448. doi: 10.1016/j.it.2012.06.005

Figure 1.

Figure 1

The subcellular site of innate immune signal transduction is defined by the localization of inflexible sorting adaptors. (a) Signaling by plasma membrane-bound Toll family members involves their recruitment to a new subdomain of the cell surface, where they can engage a sorting adaptor. For the Toll family members, the sorting adaptors TIRAP and dMyD88 are located in PIP2-rich regions of the cell surface. (b) TRIF-dependent signaling by TLR4 involves its delivery to endosomes, where the sorting adaptor TRAM resides.

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