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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 20;63(6):974–982. doi: 10.1016/j.neuropharm.2012.07.012

Figure 8. Effect of Ni2+, Ro 25-6981, and ifenprodil on NCXrev-mediated ion currents recorded with cultured hippocampal neurons.

Figure 8

In A, the ascending voltage ramp protocol employed in these experiments and three overlapping current traces obtained prior to and after switching perfusion channels to demonstrate the lack of its effect on NCXrev-mediated ion currents. 0.2% DMSO was used as a vehicle. In B-D, the effects of 5 mM Ni2+ (B), 0.5μM Ro 25-6981 (C), and 5μM ifenprodil (D) on NCXrev-mediated ion currents. The effects of inhibitors were calculated as percentage from the peak current without inhibitor taken as 100%. The time scale shown in panel D is applicable to all traces in B-D. For further details, see Materials and Methods.