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. Author manuscript; available in PMC: 2013 Feb 22.
Published in final edited form as: Nature. 2012 Aug 23;488(7412):517–521. doi: 10.1038/nature11305

Figure 3. No single Pcdhg isoform is necessary and any isoform is sufficient for dendrite self-avoidance.

Figure 3

a. SACs lacking Pcdhgc3-c5 (pcdhgtcko/fcon3;retina-cre) exhibit self-avoidance.

b. Replacement of all 22 Pcdhgs by the PcdhgC3 isoform rescues SAC dendrite self-avoidance.

c. SACs lacking Pcdhga1-a3 (pcdhgtako/tako) exhibit self-avoidance.

d. Replacement of all 22 Pcdhgs by the PcdhgA1 isoform rescues SAC dendrite self-avoidance.

e. Compared to mutants lacking all 22 isoforms, self-crossings in SACs expressing 19 or 1 isoform are restored to control levels. *** P<0.001; n.s., not significant. Bars are mean ± s.e.m, from 7 SACs from pcdhgtcko/fcon3;retina-cre retinas, 3 SACs from pcdhgtako/tako, and 9 from remaining genotypes. Scale bars, 50 μm.