Table 2.
Transmitted antiretroviral resistance trends throughout the study observation period.*
| Total N=600 | 1995–1999 N=103 | 2000–2002 N=111 | 2003–2004 N=116 | 2005–2006 N=106 | 2007–2008 N=90 | 2009–2010 N=74 | P-valuea | |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| % (N) | % (N) | % (N) | % (N) | % (N) | % (N) | % (N) | ||
| Any | 14.3 (86) | 15.5 (16) | 10.8 (12) | 21.6 (25) | 13.2 (14) | 12.2 (11) | 10.8 (8) | 0.42 |
| NRTI | 8.3 (50) | 15.5 (16) | 4.5 (5) | 13.8 (16) | 5.7 (6) | 5.6 (5) | 2.7 (2) | 0.005 |
| NNRTI | 6.8 (41) | 2.9 (3) | 5.4 (6) | 10.3 (12) | 9.4 (10) | 4.4 (4) | 8.1 (6) | 0.28 |
| PI | 4.0 (24) | 1.0 (1) | 5.4 (6) | 6.9 (8) | 2.8 (3) | 6.7 (6) | 0 (0) | 0.93 |
| Dual class | 3.2 (19) | 1.9 (2) | 2.7 (3) | 6.0 (7) | 4.7 (5) | 2.2 (2) | 0 (0) | 0.56 |
| Triple class | 0.8 (5) | 1.0 (1) | 0.9 (1) | 1.7 (2) | 0 (0) | 1.1 (1) | 0 (0) | 0.48 |
*
Antiretroviral resistance was defined as mutations in the following codons: NRTI resistance: M41L, K65R, D67N, T69ins, K70R, L74VI, Y115F, F116Y, Q151M, M184VI, T210W, T215YF and K219QE. NNRTI resistance: L100I, K101EP, K103NS, V106AM, Y181CIV, Y188CLH, G190ASC, and M230L. PI resistance: D30N, V32I, M46IL, I47VA, G48VM, I50LV, I54VTALM, L76V, V82AFTS, I84V, N88S, and L90M.
a
determined by Chi squared test for trend