Figure 1. Chemotactic activity of peritoneal lavage from control and conditional ADAM17 knockout (KO) mice following bacterial challenge.

(A and B) Two hours after i.p. injection of E. coli (5×10⁷ CFU) into control and conditional ADAM17 knockout mice, peritoneal neutrophil (A) and chemokine (B) levels were determined. Control and conditional ADAM17 knockout mice had few, if any, peritoneal neutrophils prior to infection [3]. (C) The collected peritoneal lavage fluid was also analyzed for its chemotactic activity using neutrophils from C57BL/6J WT mice. All results are expressed as the mean (±sd) of at least four mice in each group. *P < 0.001 versus control; **P < 0.05 versus control.